Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers

Abstract Background Reduction of the aortic valve area (AVA) may lead to stenosis with considerable impact on morbidity and mortality if not identified treated. Lipoprotein (a) [Lp(a)] also inflammatory biomarkers, including platelet derived have been considered risk factor for stenosis; however, association between Lp(a), biomarkers AVA among patients familial hypercholesterolemia (FH) is clear. Objective We aimed investigate relation concentration measurements velocities circulating in adult FH subjects controls. Methods In this cross-sectional study measures were examined by cardiac ultrasound markers analyzed non-fasting blood samples. The participants 64 high (n = 29) or low (n = 35) 14 healthy Results Aortic peak velocity was higher (p = 0.02), lower (p = 0.04) compared controls; when performing multivariable linear regression, there no significant differences. Furthermore, differences Lp(a) groups regarding valve. had levels platelet-derived CD40L, PF4, NAP2 RANTES controls (0.003 ? P ? 0.03). This result persisted after multiple regression. Conclusions Middle-aged, intensively treated velocity, AVA, control subjects. findings whereas maintained.